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to excess T accelerates follicular recruitment. The implications of altered ovarian programming by prenatal T excess as it relates to 1) development of multifollicular morphology (41) and early cessation ...
in ewes (56). In addition to alterations in follicular dynamics, prenatal T excess caused a reduction in the number of ovulations or culminated in anovulation. Oligo- or anovulation is a diagnostic ...
defects, a rich understanding of reproductive neuroendocrine regulation, availability of noninvasive approaches to monitor follicular dynamics, established surgical approaches to obtain hypophyseal portal ...
wave of follicular growth, it does not follow that the number of follicles recruited will be the same and result in similar endogenous levels of E2. Because prenatal T females are multifollicular, we ...
Prenatal testosterone (T)-treated ewes display a constellation of reproductive defects that closely mirror those seen in PCOS women, including altered hormonal feedback control of GnRH. Kisspeptin ...
[37]. Changes in the timing of puberty in girls with poor prenatal nutrition and growth may imply altered HPG activity; however, this requires study. One widely referenced concept that aims to explain ...
maternal metabolic alteration with fetal growth retardation (49). Animal models have also provided support for a role of the metabolic environment during prenatal life in mediating fetal growth retardation ...
increased expression of ovarian follistatin, along with reduced expression of ovarian activin beta-B mRNA, may indicate compromised intra - follicular activin availability in most follicles, thereby impairing ...
using Prism v5.0. Results Follicular development In a previous work, we characterized the alterations in follicular development in rats injected with DHEA for 15 days (50). In the present work, we ...
and, importantly, provides the enclosed follicles with inappropriate amounts of oxygen, nutrients, growth factors and hormones. The profoundly altered follicular microenvironment in PCOS is an important disruptor ...
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