Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
will only affect the locus in question. The method also takes account of any differences between the spectra of immigrant alleles and of new mutant alleles. If the genetic data come from a range of population ...
/10.1371/ However, mutation spectra of common deafness genes differ remarkably across different journal.pone.0209797 populations. Here, we performed comprehensive genetic examination and haplotype analy ...
). For statistical inference, we treat the observed SFS of s mutations as s independent multinomial draws from the expected SFS (see [45] and [50, Eq. 11] [47, Eq. 14]). This computes an approximate composite ...
, the results of the analysis of the mutation spectra using a conventional method indicated no treatment‐related differences in the spectra . In this article, we re‐examine the Big Blue® mouse findings with PPZ ...
and/or complex dystonic presentations, being on a diagnostic odyssey. Bioinformatics analyses , co-segregation studies, and sequence- interpretation algorithms were employed to detect causative mutations ...
largeDownload slide Figure 1. Point mutational spectra of the lacZ reporter gene in brain, heart, liver, spleen and small intestine from young (3.5 months) and old (32 months) mice. Bars represent the frequency ...
is likely attributable to differences in variant ascertainment between studies, underscoring the need for caution in comparisons of spectra derived from SPVs and de novo mutations . Despite this caveat, mouse ...
identified all nonsilent mutations that occurred in driver genes derived from 2 recent TCGA works9,10 and tried to identify sex-biased driver genes . Unfortunately, we found no driver gene showing difference ...
) is substantially different from the ratio of ~30:10% reported when all lung cancer types are examined and in analyses of larger data sets (see for example Hainaut & Pfeifer, 2001). A ratio of 3:1 would be quite ...
, and they highlight the importance of sequence context in analyses of genome-wide variation. Analyses of site frequency spectra (SFS) from single nucleotide polymorphism (SNP) datasets provide a powerful method ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!