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Angiogenesis is critical to the growth and metastasis of solid tumors , and acquired drug resistance is one of the major hindrances to chemotherapy . Thus, we sought a rational strategy using ...
Venous thromboembolism caused by Pt(ii)-based chemotherapy regimens increases the risk of colon cancer metastasis, recurrence, and treatment failure. Therefore, the reduction of tumor thrombosis ...
correlates with poor prognosis. Monoclonal antibodies, soluble receptors, and small‐molecule tyrosine kinase inhibitors have been developed to inhibit tumor angiogenesis , and antiangiogenic therapy is now ...
lung carcinoma, prostate cancer, some head and neck cancers, and during early colon carcinogenesis. They are often linked to disease progression. 4–6 In addition, tumor ‐induced angiogenesis requires ...
suppress the high level of ROS in cancer cells that is vital for tumor functions, angiogenesis , and metastasis. REACTIVE OXYGEN SPECIES–INDUCING CHEMOTHERAPY AGENTS Chemotherapy is the most influencing ...
of this tumor type and potential crosstalk between these key signaling pathways (which are known to play a critical role in tumor growth, metastasis, and angiogenesis ), dual inhibition of the VEGFR and EGFR ...
Abstract It has been >35 years since the link between angiogenesis and the growth of tumors was first reported. Targeting angiogenesis became feasible with the availability of bevacizumab, an anti ...
), represents a further chance of tumor control and symptom palliation for pretreated patients [6]. One of the targeted approaches most widely studied in the treatment of NSCLC is the inhibition of angiogenesis ...
for additional 72 hours. Cell viability was significantly inhibited by LLL12B (Fig 3). To investigate whether chemotherapy can be enhanced by LLL12B, the cells were treated by LLL12B combined with cisplatin ...
of cisplatin and 5-Fu to tumor cells [29,79,81] MKC-3946 IRE1α Inhibits RNase Induces apoptosis; enhances efficacy of bortezomib or 17-AAG to tumor cells [100] A-I06 IRE1α Inhibits RNase Cytotoxic to tumor cells ...
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