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The reverse mode of Na Journal of Cardiovascular Pharmacology™ 40:106–111 © 2002 Lippincott Williams & Wilkins, Inc., Philadelphia + 2 + Amiloride and KB - R7943 in Outward Na / Ca Exchange Current ...
. 385–387 + 2 + The Na - Ca Exchange Inhibitor KB - R7943 Inhibits High + 2 + K -Induced Increases in Intracellular Ca Concentration and [ H]Noradrenaline Release in the Human Neuroblastoma SH-SY5Y 1 2 1 3 ...
was inhibited by the Na + / Ca 2 + exchanger (NCX; reverse mode ) inhibitor KB - R7943 . Monensin-induced Na + loading or extracellular Na + depletion ( Na + replaced by Li + ) increased [ Ca 2 + ] i in MAECs ...
inhibition , AT receptor blockade, i 1 nonselective endothelin-receptor blockade and selective ET -receptor blockade, extracellular Na removal, and 1 21 inhibition of the reverse mode of the Na - Ca exchange ...
with physiological solution. Altogether, this suggests the reversal of NCX to a Ca2+ influx mode by the manipulation on the Na + gradient, which can be inhibited by KB - R7943 . In order to understand the low sensitivity ...
of reverse ‐ mode NCX activity) exhibited variable effects on membrane current, indicating modulation of more than one conductance. KB ‐ R7943 activated outwardly rectifying current that was inhibited by 100 μm ...
is the + 2 + Na / Ca exchanger (NCX) that, when operating in its reverse mode (NCXrev) activity, can facilitate 2 + Ca entry into neurons, possibly increasing neuronal excitability that leads to enhanced ...
inhibition of the Na + / Ca 2 + exchanger with KB - R7943 (10 µM) markedly attenuated the increase in Ca 2 + cyt via the reverse mode of Na + / Ca 2 + exchange . Store depletion also induced a rise in Ca 2 + cyt via ...
rat heart for external Ca 2 + of 0.5 and 1.5 mM under control conditions and in the presence of the reverse - mode Na + / Ca 2 + exchange inhibitor KB - R7943 (0.1 µM) in perfusate. Outflow concentration ...
of Pharmacology (2002) 135, 1096–1100; doi:10.1038/sj.bjp.0704574 Abbreviations: KB ‐ R7943 2 ‐[ 2 ‐4‐(4‐nitrobenzyloxy) phenyl]ethyl]isothiourea NCX Na + ‐ Ca 2 + exchanger SEA0400 2 ‐[4‐[(2,5‐difluorophenyl) methoxy ...
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