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that under the in vivo conditions, calcium channel blockade may prevent changes in the blood glucose and insulin concentrations induced by the CaR activation. Pharmacological Reports 71 (2019) 478–484 Contents ...
extracellular to intracellular space. Intracellular magnesium concentration has also been shown to be effective on modulating insulin action (mainly oxidative glucose metabolism), offset calcium -related ...
cause a rise in intracellular calcium levels in vitro at a ...
Sustained elevations in cytosolic calcium concentrations ([Ca2+]i) have been shown to render insulin target cells resistant to insulin action. In this study we examined the mechanisms ...
) significantly increased insulin release with stimulatory effects comparable to 1 µM glucagon-like peptide 1, which were somewhat reduced by diazoxide, verapamil and calcium -free conditions. Insulin release ...
Altered insulin secretion contributes to the pathogenesis of type 2 diabetes. This alteration is correlated with altered intracellular Ca 2+ -handling in pancreatic β cells. Insulin secretion ...
on the intracellular calcium concentration ([Ca2+]i), mitochondrial function, reactive oxygen species (ROS) generation, and secretion of insulin in freshly isolated mouse isletsof Langerhans. The hypolipidemic fibrate ...
administration. The insulinotropic effect of STX in pancreatic β-cells is mediated by the closure of the K ATP channel and the increase in intracellular calcium concentration . The in vivo improvement in glucose ...
the mechanisms by which AR-M100390 inhibits intracellular and secreted insulin in vitro and in vivo . The in vitro and/or in vivo effects of AR-M100390 were studied by measuring insulin protein and mRNA. Whereas ...
intracellular Ca2+ concentration increase. ORIGINAL ARTICLE Endocrine Research Loss-of-Function Mutation of the GPR40 Gene Associates with Abnormal Stimulated Insulin Secretion by Acting on Intracellular Calcium ...
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