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coregulators. Using the yeast two -hybrid system, we identified RanBPM as a new protein partner for TRs. RanBPM was initially discovered as an interacting partner for Ran, and was also shown to be a protein ...
AbstractMore than two dozen androgen - responsive genes were identified from the castrated rat ventral prostate on the basis of their induction by exogenous testosterone. One of the identified genes ...
of the AR from alligator cDNA, which lacks seven amino acids within the ligand-binding domain that shows no response to androgens . Finally, we have initial data on a possible dominant-negative function ...
for the function of this region . Figure 2 View largeDownload slide Characterization of the effect of mutations in region A of PSA promoter on androgen inducibility. PC-3 cells in duplicate plates were cotransfected ...
The androgen receptor (AR) N-terminal domain plays a critical role in androgen - responsive gene regulation. A novel AR N-terminal-interacting protein (ARNIP) was isolated using the yeast two -hybrid ...
encompasses the androgen receptor gene promoter. DNA was extracted from blood leukocytes and the polymerase chain reaction was used to amplify the promoter region as two overlapping products. Single strand ...
that is classically characterized as a disorder of hormone action due to a reduced or absent functionality of the androgen receptor (AR) protein encoded by the AR gene. AIS is often suspected to be a common cause ...
region , and a 1330-bp 3′-untranslated region ending with a poly-A tail (Supplemental Figure 1). Examination of the deduced Mr-IR amino acid sequence identified conserved domains that characterize reported ...
and characterization of two androgen response regions in the human neutral endopeptidase gene. Mol Cell Endocrinol 170 : 131 – 142 Google Scholar Crossref Search ADS PubMed WorldCat 8 Papandreou CN , Usmani B , Geng Y ...
) of androgens repress expression of GC79 messenger RNA (mRNA) in LNCaP-FGC cells. To determine the role of GC79, we cloned its complementary DNA (cDNA) and functionally characterized its product. Methods ...
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