Bone 40 (2007) S267 â S313 www.elsevier.com/locate/bone Abstracts 081Th Low dose X-irradiation facilitated fracture callus mineralization in a rat model X.Z. Zhou1, G. Zhang2, Q.R. Dong1, J. Zhang1, W.Y. Hung2, H. Sheng2, C.W. Chan2, W.H. Cheung2, K.S. Leung2, L. Qin2 1 Department of Orthopaedics, The 2nd Affiliated Hospital, Suzhou University, Suzhou (215004), China 2 Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China Introduction: X-irradiation at high dose (HDI) impairs fracture healing. On the contrary, it has been reported that Xirradiation at low dose (LDI) promoted tissue revascularization, which critically precedes callus mineralization during fracture healing process. However, it still remains unclear whether LDI exerted beneficial effect on fracture callus mineralization, which provides local mechanical stability for early rehabilitation of fracture patients. Aims: To investigate the effect of LDI on fracture callus formation and mineralization evaluated using radiography, micro-CT, peripheral quantitative computed tomography (pQCT) and biomechanical test in a standardized rat femoral fracture model. Methods: 120 male SpragueâDawley rats were subjected to standard closed fracture on right femur. Sixty rats of which were irradiated with low dose X-ray (1 Gy as LDI group) for total body irradiation right after fracture induction. The remaining
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