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human studies have examined salvinorin A. Objective This double-blind, placebo-controlled study evaluated the dose -related effects of inhaled salvinorin A in individuals with histories of hallucinogen use ...
will be necessary to study the effects of SA in humans . Psychopharmacology (2011) 214:933–939 DOI 10.1007/s00213-010-2103-5 ORIGINAL INVESTIGATION Lack of effect of sublingual salvinorin A, a naturally occurring ...
Salvinorin A is a kappa opioid agonist and the principal psychoactive constituent of the Salvia divinorum plant, which has been used for hallucinogenic effects . Previous research on salvinorin ...
The present results indicate similarities as well as differences between the subjective effects of S. divinorum and other hallucinogens. As a selective kappa opioid receptor agonist, SA may be useful ...
The inhibitory effect of salvinorin A on striatal dopamine levels may contribute to its induction of conditioned place aversion and decreases in locomotion in mice. These findings are consistent ...
of this opioid system contributes to cognitive deficits and other behavioral abnormalities associated with psychiatric disorders are warranted. Rationale Kappa -opioid receptor (KOR) agonists produce dysphoria ...
was designed to test dose - and time-course effects of novel kappa opioid receptor antagonists with the goal of identifying short-acting lead compounds for future medication development. Methods We screened 2 ...
, on the effects of systemic salvinorin A on extracellular dopamine in the caudate putamen (Zhang et al., 2005), and the effects of systemic salvinorin A on rotarod incoordination (White et al., 2015). At a dose ...
physiological saline and administered intraperitoneally (i.p.). NorBNI produces significant effects on neurotransmitter content and behavioral phenotypes in preclinical models at 1–30 mg/kg dose (Zhang et al ...
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