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Abstract: Chronic alcohol misuse by human subjects leads to neuronal loss in regions such as the superior frontal cortex (SFC). Propensity to alcoholism is associated with several genes . γ ...
subunit expression in the human alcoholic brain , by Tracey Buckley and Peter Dodd; (2) NMDAR gene expression during ethanol addiction, by Jorg Puzke, Rainer Spanagel, Walther Zieglgansberger, and Gerald ...
Altering the expression of specific genes in the brain is one of the mechanisms through which the organism may adapt to chronic alcohol exposure. Several molecular biology methods allow researchers ...
Chronic alcohol exposure causes widespread changes in brain gene expression in humans and animal models. Many of these contribute to cellular adaptations that ultimately lead to behavioral tolerance ...
. Innate immune gene activation in brain is persistent, consistent with the chronic relapsing disease that is alcoholism . Expression of HMGB1, TLRs, and other ISMs is increased several-fold in the human ...
Alcohol dependence may result from neuroadaptation involving alteration of gene expression after long‐term alcohol exposure. The systematic study of gene expression profiles of the human alcoholic ...
in neurotransmission and signal transduction. These data support the concept that, within cortical regions, changes in gene expression are associated with alcoholism ‐related pathology. In the dopaminergic tract ...
We performed gene therapy to induce expression of GDNF in the ventral tegmental area of rhesus monkey brains . Our approach countered the hypodopaminergic state that is associated with chronic alcohol ...
We analyzed global patterns of expression in genes related to glutamatergic neurotransmission (glutamatergic genes ) in healthy human adult brain before determining the effects of chronic alcohol ...
transcript expression levels (mQTL) with a genomic region that regulates alcohol consumption (bQTL). To address a controversy regarding utility of gene expression profiles from whole brain , vs specific brain ...
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