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positive for BCR-ABL1 BCR-ABL1 299 60 Yes No AML with BCR-ABL1 51-69,XY,+y,+1,+2,+3,+6,i(6)(p10),+ 8 , t (9;22)(q34;q11.2), +10,+11,+12,+13, del(13)(q12q14),+14,+ 15 ,+16,+18,+19, +20, +der(22) t (9;22)[cp4]/46,XY ...
and prognosis of adults with acute myeloid leukemia (AML). The most frequent chromosome/molecular rearrangements, that is, t (8;21)( q22 ; q22 )/RUNX1-RUNX1T1 and inv(16)(p13q22)/ t (16;16)(p13; q22 )/CBFB-MYH11 ...
or with FLT3-ITDlow (without adverse-risk genetic lesions) t (8;21)( q22 ;q22.1); RUNX1-RUNX1T1 with mutated KIT inv(16)(p13.1; q22 ) or t (16;16)(p13.1; q22 ); CBFB-MYH11 with mutated KIT trisomy 8 Adverse/Poor t (6;9 ...
of abnormalities, particularly rearrangements of KMT2A (previously known as MLL) and RUNX1-RUNX1T1 fusion ( associated with t (8;21)( q22 ;q22.1)). In a large series of 92 myeloid sarcoma cases by Pileri et al,2 8.5 ...
panel reviewed 109 cases, assigned consensus diagnosis, and created diagnosis-specific sessions. Results The most frequent diagnosis was reactive eosinophilia (35), followed by acute leukemia (24 ...
findings at diagnosis and follow-up (cases 11-14). Cases 15 and 16 showed low-level gains of RUNX1T1 and RUNX1 and relapsed with trisomy 8 and trisomy 21 , respectively. The final case from the karyotype ...
biopsies were obtained from four human leukemic patients diagnosed with AML carrying the t (9;11)(p22;q23) [35], del(5)(q13q33) [36], trisomy 4 (+4) [37] and del(16)( q22 ) [38], or trisomy 8 (+ 8 ) [39] leukemia ...
WorldCat 10 Baer MR , Stewart CC, Lawrence D, et al. Expression of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t (8;21)( q22 ...
Induction response to prednisone on day 8 No peripheral blasts Peripheral blasts CNS status CNS 1 CNS 2 or 3 Cytogenetics Trisomies 4 and 10 t (4;11), t (9;22) Molecular genetics TEL-AML1 MLL gene ...
)( q22 ;q25),19q + , + dup(1)(q23-q32)S646,XX6/100 (6.0)4/100 (4.0) . . . 8 /17 (47.1)del(2)(p23-q23),del(5)( q22 ), + ace,del (4)(q28), t (1;6)(p34;q36) + t (7;12)(q36;q15),del(1)(p34),del(12)(q15) + ace + ace ...
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