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, however, is not always absolute, causing the AHR to fluctuate between reversible states of expression and repression , with a fraction of the cells escaping repression at any one time. Cells that escape AHR ...
, endoderm, and mesendoderm. This profound alteration in biological behavior occurred in the face of continued expression of factors known to induce pluripotency, including Oct4, Sox2, and Nanog . We present ...
, chromatin remodeling, gene regulation and DNA repair, may contribute to its oncogenic functions. Figure 2. Open in new tabDownload slide DAXX mRNA expression in cancer. (A) Boxplots depicting DAXX mRNA ...
affect multiple genes in a coordinate manner. Several studies have suggested that TE insertions have contributed to the rewiring and evolution of regulatory networks by recruiting multiple genes ...
, plays important roles in maintaining the genomic stability of EScells. Upon DNA damage, p53 quickly binds to the promoter of Nanog and represses its expression . The loss of Nanog leads ...
maturation phase. (B): Morphology and immunocytochemical analysis of SSEA-4, Tra1–60, and Nanog expression in representative compact and non-compact colonies. (C): Global expression analysis strategy ...
), Lag-1, is an evolutionarily conserved protein that binds to the motif CGTGGGAA (24,25). The default activity of RBPJ is often considered to be transcriptional repression ; RBPJ accomplishes this task ...
/CYTOR (identified within this class) binds and recruits EZH2 to its target promoters p15 and p21 in gastric cancer [83] and IL24 in lung cancer [84] and thereby causes repression of their expression ...
− cells have the hallmarks of an epithelial cell progenitor population. Isolated EPCPs express pluripotency factors and markers of the epithelial cell lineage Runx1 and EpCAM, and they form acini and ducts ...
reprogramming is that repeated daily mRNA transfections are required over several days for continuous expression of reprogramming factors. Thus, the repression of immunogenicity against exogenously delivered mRNA ...
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