“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $30/month

Get 2 Weeks Free

Findings of a Relation Between Vitamin D and C-Reactive Protein: Concerns About Methods Used and Conclusions Drawn

Findings of a Relation Between Vitamin D and C-Reactive Protein: Concerns About Methods Used and Conclusions Drawn The epidemiologic study suggesting a relation between serum 25-hydroxyvitamin D (25[OH]D) and C-reactive protein (CRP) by Amer and Qayyum 1 is timely, given the prominence of 25(OH)D in recent scientific research and the recent increase in vitamin D recommended daily allowances. 2 However, the study appears to suffer from deficiencies in internal validity (due to the analysis methods used) and external validity (because vitamin D supplementation by subjects was not included in the analysis). Their findings contradict evidence for a dose-dependent reduction of coronary heart disease mortality with higher serum 25(OH)D, 3 and furthermore, CRP has questionable utility in guiding treatment of patients with coronary heart disease. 4 Best practices in data analysis suggest several steps that should have been taken to avoid bias and uncertainty. The scale of the y axis in Figure 1 should have been back-transformed from the logarithm of CRP to its raw (original) value. The investigators' multivariate analysis results are counterintuitive, because in Table 1, we can read that subjects with 25(OH)D levels <21 ng/ml had higher mean CRP levels than subjects with 25(OH)D levels >21 ng/ml. An appropriately scaled graph would allow readers to visually grasp the relations being examined and assess http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Cardiology Elsevier
Loading next page...
 
/lp/elsevier/findings-of-a-relation-between-vitamin-d-and-c-reactive-protein-vILXnQp12r

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for just $30/month

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.