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, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D. Role of substrates and products of PI 3 - kinase in regulating activation of Rac-related guanosine triphosphatases by Vav ...
, kinases play a pivotal role in biochemical reactions involved in protein, lipid and nucleotide metabolism (Box 1). However, the exact role these alterations play in motor neuron degeneration remains elusive ...
Abstract Inorganic phosphate ( Pi ) plays a key role in diverse physiological functions. Recently, considerable progress has been made in our understanding of the function and regulation of the brain ...
of extracellular signal-regulated kinases . Moreover, mice lacking SOD2 (SOD2−/− mice) exhibit significantly fewer proliferative NPCs and differentiated neurons in the embryonic cerebral cortex at midgestation ...
present the concept that the SDF‐1–CXCR4 axis is a master regulator of trafficking of both normal and cancer stem cells. Supporting this is growing evidence that SDF‐1 plays a pivotal role in the regulation ...
phosphorylation (a key capacitation event) after sperm–OVS interaction, provides strong evidence for the pivotal role of OVS in regulating female fertility. Materials and Methods Ethical approval The studies were ...
to phosphatidylinositol 3 - kinase ( PI 3 - kinase ). Although EGF is known to activate PI 3 - kinase activity in some cells, the EGF receptor does not appear to contain a motif for the recruitment of PI 3 - kinase . However, ErbB3 ...
-studied examples of the latter are plasma-membrane-associated lipid cascades incorporating, among others, phospholipases C ( PI -PLCs), phosphoinosotide 3 - kinases (PI3Ks), and/or phospholipase D (PLD) [26 ...
in response to DNA-damaging agents (32). Collectively, the ATM–Mdm2–p53 pathway plays a pivotal role in this cellular response to DNA damage. Here, we investigate the role of LRRK2 in the response to DNA damage ...
significantly inhibited HepG2 cell proliferation and severely hindered their migration and invasion potentials. Our results demonstrated that NRSF plays a pivotal role in promoting DEN-induced HCC initiation via ...
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