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, the investigation of crosstalk between ERK and CREB revealed that p- CREB activation by fisetin occurred through the ERK -independent pathway. Moreover, we demonstrated that fisetin effectively counteracted ...
were reduced , HMGB1 nuclear translocation and release were inhibited. The activation of rhHMGB1-induced Akt-mTOR-P70S6K and ERK - CREB signalling pathways was inhibited by ALO. Blocking these signalling ...
signaling pathway [16]. Enhanced p38 MAPK phosphorylation can activate its substrates including ATF-2 and CREB . In H9c2 rat heart cells, however, Cd exposure reduced the phosphorylation of AKT [37]. According ...
phosphorylation via PI3K and Akt consequently reducing β-catenin phosphorylation. EP4 induces angiogenesis by enhancing VEGF production via ERK activation . These effects of EP4 are asserted either directly or via ...
good BBB penetration ability, with brain to plasma ratio of 5.3%, in in vivo pharmacokinetic assessment. Our results indicate that LM-021 works as a CREB enhancer to reduce Aβ ...
the expression of phosphorylated CREB (Ser 133) to 10.95% of the values found in control, means of 2.19 ± 0.58 for C0 and 0.24 ± 0.11 for D0. In turn, LPLI significantly (P = 0.000) enhanced the activation ...
factor-kappa-light-chain- enhancer of activated B-cells (NF-κB), cyclic adenosine monophosphate response element binding protein ( CREB ), and heat shock element (HSE), as well as caspase-3 cleavage ...
death in ES cells Inhibition of CD99 by clofarabine or antibodies results in apoptosis of ES cells. Since we observed rapid activation of ERK1/2, MSK1/2, and CREB phosphorylation following CD99 inhibition ...
-regulated kinase 1/2 ( ERK ) and AKT serine/threonine kinase (AKT), to activate ribosomal S6 kinase (RSK) and cAMP response element-binding protein ( CREB ). Subsequently, p- CREB enhanced the transcription of pro ...
activation by M.tb in human macrophages. Download: PPT PowerPoint slide PNG larger image TIFF original image Fig 2. M.tb-induced CREB activation is p38- dependent and ERK -independent. A) MDMs were infected ...
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