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Journals Seminars in Arthritis and Rheumatism Volume 38 Issue 2

Cardiovascular (CV) disease is the most common cause of mortality in patients with rheumatoid arthritis (RA) ( 1,2 ), a consequence of accelerated atherosclerosis ( 3,4 ). Both traditional and nontraditional CV risk factors are associated with atherosclerosis in RA ( 5-7 ). The presence of chronic inflammation is responsible for the development of subclinical atherosclerosis ( 8,9 ) and increased incidence of CV events in these patients ( 7 ). The magnitude and chronicity of the inflammatory response measured by C-reactive protein correlated directly with the presence of subclinical atherosclerosis in RA patients without clinically evident CV disease ( 9 ).</P>At present, several noninvasive imaging techniques offer a unique opportunity to study the relation for surrogate markers to the development of atherosclerosis. The use of these techniques may help identify high-risk individuals who may benefit from active therapy to prevent clinical disease. In the present issue of Seminars in Arthritis and Rheumatism Rojas-Villarraga and coworkers emphasize the importance of 2 noninvasive techniques, the evaluation of endothelial function by flow mediated (endothelium-dependent) vasodilatation (FMD) and the evaluation of carotid intima-media thickness (IMT) by high-resolution B-mode ultrasonography, in the assessment of subclinical atherosclerosis of South-American patients with RA (

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Endothelial Dysfunction, Carotid Intima-Media Thickness, and Accelerated Atherosclerosis in Rheumatoid Arthritis

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  • Publisher Elsevier
  • Copyright Copyright © 2008 Elsevier Inc.
  • ISSN 0049-0172
  • D.O.I. 10.1016/j.semarthrit.2008.02.001
  • Publisher site Get PDF  

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