Effect of pilsicainide, a pure sodium channel blocker, on spiral waves during atrial fibrillation: theoretical analysis by numerical simulation

Tsunetoyo Namba; Takashi Ashihara; Kazuo Nakazawa; Tohru Ohe

doi:10.1016/S0022-0736(99)90003-1

$This study investigated the effects of a particular type of sodium channel blocker, pilsicainide, on spiral waves, which are a possible mechanism of atrial fibrillation, by using numerical simulation. A meandering spiral wave was induced on a two-dimensional matrix corresponding to the isolated atrial myocardium. The model attempted to simulate the changes caused by pilsicainide. The conductivity was depressed and the refractory period was prolonged with little change in the action potential duration. The dynamic change in the refractory period depended on the preceding coupling interval. A blockline occurred and changed gradually because of the change in the refractory period. The spiral wave became a stable reentry rotating around the blockline, decreasing the excitation frequency in the matrix before rushing out of the matrix. The electrocardiogram showed a slow coarse wave, as well as a real electrocardiographic change by pilsicainide. This might, in part, explain how pilsicainide acts on atrial fibrillation.$

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Effect of pilsicainide, a pure sodium channel blocker, on spiral waves during atrial fibrillation: theoretical analysis by numerical simulation

Namba, Tsunetoyo; Ashihara, Takashi; Nakazawa, Kazuo; Ohe, Tohru

Follow Journal of Electrocardiology , Volume 32 (4) Elsevier – Oct 1, 1999

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Effect of pilsicainide, a pure sodium channel blocker, on spiral waves during atrial fibrillation: theoretical analysis by numerical simulation

Namba, Tsunetoyo; Ashihara, Takashi; Nakazawa, Kazuo; Ohe, Tohru

Follow Journal of Electrocardiology , Volume 32 (4) Elsevier – Oct 1, 1999

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