Soszyński, Mirosław; Bartosz, Grzegorz
Effect of peroxynitrite on erythrocytes
The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1–2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities. Membranes exposed to peroxynitrite showed aggregation and nitration of proteins and changes in protein organization detectable with a maleimide spin label.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngBiochimica et Biophysica Acta (BBA) - General SubjectsElsevierhttp://www.deepdyve.com/lp/elsevier/effect-of-peroxynitrite-on-erythrocytes-BM99eNIxCg