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-Response of 1,2:3,4-Diepoxybutane–Specific N-Terminal Valine Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene , 1 , , , 1 , , , 2 Nadia I. Georgieva,* Gunnar Boysen,* † ‡ Narisa Bordeerat ...
with DNA . We have previously reported a quantitative nanoLC/ESI+-HRMS3 method for urinary N7-( 1 -hydroxy- 3 -buten- 2 -yl) guanine (EB-GII) adducts as a mechanism-based biomarker of BD exposure . In the present ...
of monohydroxy- 3 -butenyl mercapturic acids (MHBMA). The reactive metabolite 1,2- epoxy - 3 -butene forms 1 - and 2 -hydroxy- 3 -butenyl valine adducts in hemoglobin (MHBVal). The objectives of the study were ( 1 ...
, Tareke et al. (2006) administered acrylamide via drinking water to male and female F344 rats and assayed adducts in DNA (N7-GA-Gua) and in hemoglobin (AAVal and GAVal) after 1 , 3 , 7, 14 , 28, 42, and 50 ...
exposure . Rats were exposed in a 15-liter whole body plastic inhalation chamber. MDI condensation aerosols were generated by bubbling 4 l/min or 1 l/min of dry, clean air through an impinger containing 4 g ...
. Google Scholar Chen, H.-J. C ., Zhang, L., Cox, J., Cunningham, J. A., and Chung, F.-L. ( 1998) DNA adducts of 2,3- epoxy - 4 -hydroxynonanal: Detection of 7-( 1 ′, 2 ′-dihydroxy-heptyl)-3H-imidazo[2,1,i]-purine ...
). EB produces N-( 2 -hydroxy- 3 -buten- 1 -yl)-valine (HB-Val) and DEB forms N,N-(2,3-dihydroxy-1,4-butadiyl)-valine (pyr-Val) and 2,3,4-trihydroxybutyl-valine (THB-Val). The later adduct is primarily formed ...
levels of adducts formed. Thus, an acute exposure of V79 cells was gained by treatment with BPD (the 7,8-trans-dihydrodiol of BaP) for 3 h using a cell line, XEM2, expressing CYP1A1, and preparing DNA ...
phases such as DNA replication (G 1 arrest) and cell division (G 2 arrest) ( 9 – 14 ). Tumor suppressor proteins such as p53, p21 waf1/cip1 and pRb play crucial roles in the protective cellular response ...
′‐A*TTT‐5′ G 0.021 1.03 × 10– 3 0.017 8.3 × 10– 3 A 0.024 1.24 × 10– 3 0.03 1.47 × 10– 2 T 19.3 1 2.04 1 C 0.012 6.2 × 10– 4 0.0014 6.8 × 10– 4 3 ′‐A*GAC‐5′ G 0.002 1.5 × 10– 4 ...
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