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on a family of multidomain, integral membrane proteins called the MDC (metalloproteinase- like , disintegrin - like , cysteine - rich ) or ADAM (a disintegrin and metalloprotease) family (see Table I). Many ...
domain might be released autocatalytically or by the action of another unknown protease activity (8, 9). Class P-III enzymes consist of proprotein, metalloprotease, disintegrin - like and cysteine - rich ...
proportion of positively selected codon sites in the disintegrin / cysteine - rich region of genes expressed in the testis ( ADAMs 2 and 32) (fig. 3). Similar results were found for ADAM 1, a heterodimer of ADAM 2 ...
metalloproteinase. This suggests that eMDC II has proteolytic activity . cysteine - rich protein, disintegrin - like , epididymis, metalloproteinase, metalloproteinase- like Introduction Following spermatogenesis ...
) showed sites within adhesion domains ( disintegrin and cysteine - rich ) of fertilin β evolving under positive selection. The region 3′ to the EGF- like domain of fertilin α, where the transmembrane ...
evidence that fertilin is but one of a conserved family of related cysteine - rich proteins, now designated as ADAM (a disintegrin and a metalloproteinase), that contain metalloproteinase- like and disintegrin ...
-terminal signal sequence followed by a prodomain, a metalloproteinase domain, a disintegrin domain, a cysteine - rich region , an epidermal growth factor (EGF) domain, a transmembrane domain and a cytoplasmic ...
ADAMs and are large multidomain toxins (60–100 kDa) built up by an N-terminal metalloproteinase domain and C-terminal disintegrin - like and cysteine - rich domains. The class PII metalloproteinases (30–60 ...
and invertebrates [79, 80]. They are cysteine - rich molecules that selectively block the function of integrin receptors on the cell membrane surface [81, 82], exhibiting a thrombospondin- like (TS) repeat ...
substrates. ADAMs have distinct characteristic domains, pro-peptide (P), metalloproteinase (M), disintegrin - like (D), cysteine - rich (C), epidermal growth factor- like (EGF), transmembrane (TM) and cytoplasmic ...
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