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into 5 groups: collagenases ( MMP -1, MMP -8, and MMP - 13 ), gelatinases ( MMP -2 and MMP -9), stromelysins ( MMP - 3 , MMP -10, and MMP -11), membrane-type MMPs , and others. Matrix metalloproteinases are normally ...
progenitor cells expressed very low levels of MMPs or TIMPs. The transcription of a number of MMP and TIMP mRNAs [Str1, MT1- MMP , ( MMP -14) collagenase - 3 ( MMP - 13 ), gelatinase A ( MMP -2), and TIMP-1, -2 and - 3 ...
, Solomon A, Lokeshwar BL, Pflugfelder SC. Regulated expression of collagenases MMP -1, -8, and - 13 and stromelysins MMP - 3 , -10, and -11 by human corneal epithelial cells . Invest Ophthalmol Vis Sci 2003 ; 44 ...
metalloproteinases ( MMP ) 1 ( collagenase ) and 3 ( stromelysin ). Northern blot analysis of rabbit brain showed that MMP ‐1 in particular is expressed in the immature rabbit cerebrum and down‐ regulated during maturation ...
Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix metalloproteinases ( MMPs ). We previously found MMP - 3 ...
, the MMPs can be classified into four major subgroups: collagenases ( MMP -1, - 13 , -8), gelatinases ( MMP -2, -9), stromelysins ( MMP - 3 , -10, -11, -19), and membrane-type metalloproteinases (MT- MMP -1–5 ...
( MMP ‐1, MMP ‐8, MMP ‐ 13 , and MMP ‐18), gelatinases ( MMP ‐2 and MMP ‐9), stromelysins ( MMP ‐ 3 , MMP ‐10, and MMP ‐11), membrane‐type MMPs (MT‐ MMPs ) ( MMP ‐14, MMP ‐15, MMP ‐16, MMP ‐17, MMP ‐24, and MMP ‐25), minimal ...
, intestine MMP -11 Stromelysin - 3 Gelatin TIMP-1, -2 MMP -12 Metalloelastase Elastin TIMP-1, -2 Placenta, Mφ, stromal cells MMP - 13 Rodent Collagen I, II, III MT- MMP LIF, TNFα, IL-1β Widely including heart ...
Collagens I, II, III, VII and basement membrane components Collagenase 3 MMP - 13 Collagens I, II, III Gelatinases Gelatinase A MMP -2 Gelatins, collagens I, II, III, VII and basement membrane components ...
. Collagenases MMP -1 ? a[67] ↓ [68] ↓ [79] MMP -8 MMP - 13 Gelatinases MMP -2 ↑ [64] ↑ [70] ↓ [73,74] ↑ [77] MMP -9 ↑ [64] ↓ [66] ↓ [72,74] ↑ [80] Stromelysin MMP - 3 MMP -10 MMP -11 Matrilysin MMP -7 ↑ [64] Metalloelastase ...
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