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and palmitoyl‐ l ‐carnitine oxidation in rats treated with different chain‐length 3‐thia fatty acids. CPT ‐ I activity and mRNA levels were, however, marginally affected. The hepatic CPT ‐ II activity was mainly ...
), a specific and irreversible CPT inhibitor of the malonyl-CoA sensitive CPT isoform ( CPT I ). TDGA treatment of adult type II pneumocytes caused a significant reduction in the incorporation of radioactive ...
77843-4458 ABSTRACT very different kinetic properties and sensitivity to malonyl- CoA. The human genes for L and M- CPT I reside on chro- Because we had found whole testis from adult rats to be mosomes ...
and pig L -CPTI, and deletion mutation analysis, we demonstrated that the differences in malonyl-CoA sensitivity observed between the pig and rat L -CPTI were due to differences in the interaction ...
groups (five mice per group): ( i ) Control (receiving i.p. saline injections every 2 days); ( ii ) PSD (receiving i.p. 5 mg/kg of PSD every 2 days; PSD was dissolved in saline); (iii) CPT (receiving i.p. 3 mg ...
. Surprisingly, MCF-7 cells were shown to be resistant to both iAsIII and CPT when used alone; however, they were shown to be relatively sensitive to treatment when exposed to MMAIII and DMAIII alone. Conversely ...
). Like camptothecin, CPT -11 acts by inhibiting mammalian DNA topoisomerase I (12)(13). Cell death results from stabilization of cleavable complexes formed between topoisomerase I and DNA during DNA ...
, multidrug resistance-associated protein 2 Introduction Irinotecan hydrochloride ( CPT -11), a topoisomerase I inhibitor, is widely used in clinical practice as a chemotherapeutic agent to treat lung cancer ...
to be much more sensitive to the combination treatment of iAsIII and CPT at sub-toxic concentrations of 1 μM and 15 μM respectively and the cells viability was reduced to approximately 50% of control. In fact ...
in a mixture of 4% ethanol plus 4% Tween 80, while CPT -11 and TPT were diluted in distilled water. Wing spot test Two D.melanogaster strains carrying markers on the left arm of chromosome 3 were used: ( i ) flr3 ...
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