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of chondrocytes [119, 120]. Although chondrocytes appeared to maintain high proliferative capacity when cultured in collagen type I, there was a gradual loss of differentiated phenotype [151]. To enhance ...
the collagen fiber network by exerting a force on it, and, in return, the stiffened collagen promotes tumor cell migration and force generation [20, 33]. Although the field of quantitative measurements of force ...
cartilage repair include microfracture, autologous chondrocyte implantation, osteochondral autograft, and allograft transplantation [5]. Especially for large areas of full-thickness articular cartilage ...
in a tissue-autonomous manner. Joints are formed at the articulations between skeletal elements and are made up of force -absorbing articular chondrocytes (permanent cartilage) that secrete an oily lubricating ...
stimuli cause extensive proliferation of resting chondrocytes . The proliferating chondrocytes express specific markers such as collagen type II and aggrecan, whose production is regulated by chondrogenic ...
on the reprogrammed cell source [23]. Intuitively, the stiffness of hPSCs was found to be significantly lower than differentiated cells, including fibroblasts, articular chondrocytes , mesenchymal stem cells ...
and are capable of degrading all the matrix components of the heart, are the driving force behind myocardial matrix degradation during remodeling. Thus, an increase in MMP activity may result in fibrillar collagen ...
for a total of 60 seconds upon the cantilever's indentation. A maximum force trigger of 3.0 ± 0.5 nN, which generated about 30–50% cell strain, was implemented to designate the point at which the cantilever ...
: Nitric oxide mediates IL-1 induced gene expression of MMPs and bFGF in cultured rabbit articular chondrocytes . J Biochem 1998 ; 123 : 431 – 439 . Google Scholar Crossref Search ADS PubMed WorldCat 8 ...
of these collagen fibres provides strength to cartilage tissue, and in OA, degradation of these collagen fibres is thought to be critical and perhaps irreversible [30]. In an in vitro study, chondrocytes co-cultured ...
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