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that was over and above loss of neurons in the CA1 subregion. Here, we report the first direct comparison of in vivo cBZR binding with (11C)FMZ‐PET and ex vivo binding using (3H)FMZ autoradiography. We applied ...
the hippocampus, entorhinal/piriform cortex, and amygdala, thus attenuating hippocampal synapse loss , neuronal death, neuroinflammation and brain atrophy. At the molecular level, the loss of forebrain BIN1 elicited ...
in hippocampal sclerosis (HS). It has been uncertain whether reduced cBZR binding is entirely due to neuronal loss in HS. 2 The objective of this study was to characterize abnormalities of the cBZR in HS ...
on postischemic hippocampal neuronal death in a model of Japanese monkeys (Macaca fuscata) undergoing a 20-min complete whole-brain ischemia. Using the same model here, we investigated the in vivo bindings of two ...
Decreased 5‐HT1A receptor binding has been associated with Alzheimer's disease (AD) and interpreted as a consequence of neuron loss . The purpose of the present study was to compare [11C]WAY100635 ...
deficits of MeCP2-deficient neurons in vitro but not in vivo . In addition, (1–3) IGF-1 treatment corrected aberrant excitability and network synchrony of MeCP2-deficient hippocampal neurons . Our results ...
-brain GABAA binding potential in vivo using [11C]-flumazenil positron emission tomography and compared GABAA binding with metabolic and volumetric measurements. For this purpose, we studied 12 subjects ...
by demonstrating a recovery of 5‐HTT binding sites in young, but not old animals, at 21 days following the lesion (P < 0.001). Furthermore, cellular electrophysiological function of hippocampal CA1 pyramidal neurons ...
associated with accumulation of Amyloid β (Aβ plaques), hyper-phosphorylated misfolded Tau, and neuronal loss [1–3]. Susceptibility loci that contribute to Late Onset of AD (LOAD) have been identified ...
neuropathological finding characterized by pervasive loss of neurons and gliosis in the CA1 and subiculum regions of the hippocampus. While hippocampal sclerosis at younger ages is associated with epilepsy, in later ...
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