Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
ADS PubMed 20. Garner , R.C. et al. ( 1999 ) Comparative biotransformation studies of MeIQx and PhIP in animal models and humans . Cancer Lett ., 143 , 161 – 165 . Google Scholar Crossref Search ADS ...
. The mutagenicities of these five HCAs were significantly decreased in the presence of liver S9 from rats pretreated with a combination of PhIP and ANIT as compared with that pretreated with PhIP alone. The level ...
or constituents present in the food. Introduction An important aspect that should be taken into account when assessing the risk of food-borne toxic compounds is whether results from long-term animal studies ...
is more important for 2-ring heterocyclic amines such as PhIP (32). We compared the ability of ATP to activate both N-OH-IQ and N-OH- PhIP under the same conditions (Table I). In addition, AcCoA and PAPS ...
. No induction of MN was observed with PhIP and IQ. Cytotoxicity but no genotoxicity was observed with acrylamide treatment. Discussion The aim of this study was to explore the capacity of the differentiated ...
I. All the remaining compounds were selected from the initial GADD45a–GFP validation study without metabolic activation (6), in which comparative data and further details are available. Compounds ...
(McQueen et al., 2003). Although there are species differences in the developmental expression of biotransformation enzymes, these animal studies support the more limited data available from humans. NAT1 ...
known to play an important role in lung and oral cancers among smokers (30,31), suggesting that the hamster is a suitable animal species for studying CS-induced carcinogenesis. Further, CS might enhance ...
by JEMS/BMS (Bacterial Mutagenicity Test Study Group) members and the Human and Animal Bridging Research Organization (HAB). In this study , the mutagenicity of 58 chemicals, many of which were judged ...
with an equal amount of 1N HCl, (B) TE buffer (50mM Tris-HCl and 10mM EDTA [pH 7.0] with H2O2 [175mM] for 20h, or (C) TE buffer (pH = 7.0) for 20h. Animal studies : DNA adduct formation in liver and extrahepatic ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!