“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

Clonal cytogenetic abnormalities in the plasma cell variant of Castleman disease

Clonal cytogenetic abnormalities in the plasma cell variant of Castleman disease Castleman disease (CD) is widely regarded as a non-neoplastic process, yet clonal cytogenetic abnormalities have been rarely reported and are restricted to the hyaline–vascular variant. It remains unclear whether this reflects true rarity in such tumors - the fact that such cases are not routinely submitted for cytogenetic studies, or that suspension culture techniques are erroneously used rather than in situ cultures. We report a localized plasma cell variant of CD (PC-CD) with clonal abnormalities. A human immunodeficiency virus–negative 35-year-old man sought care for vague abdominal pain and was found to have an isolated 6-cm mesenteric mass. PC-CD was diagnosed by integrating clinical, laboratory, morphologic, and immunophenotypic studies. Flow cytometric, immunohistochemical, and molecular IGH@ gene rearrangement studies were all negative for a clonal B or plasma cell population. A cytogenetic in situ culture analysis revealed an abnormal karyotype: 46,XY,add(6)(p23),add(7)(p15),del(7)(p15),add(9)(q22)(4)/46,XY,inv(9)(p13q22)(2)/46,XY,−3,+r(2)/46,XY(3). A cytogenetic suspension culture showed a normal karyotype. On the basis of the morphologic and immunophenotypic features, these genetic changes are attributed to the non-lymphoid cells, most probably of stromal, dendritic, or endothelial origin. Because the pathogenesis of PC-CD is not thought to typically involve the proliferation of these cell types, this is a new and unexpected finding and may provide pathogenetic insight. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Genetics Elsevier
Loading next page...
 
/lp/elsevier/clonal-cytogenetic-abnormalities-in-the-plasma-cell-variant-of-LK7sfSIFfi

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.