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and AD pathogenesis. ACAT Acyl-coenzyme-A cholesterol Genetic polymorphisms in genes regulating the pivotal acyltransferase points in cholesterol metabolism have been suggested to AD Alzheimer’s disease ...
of Alzheimer ’ s disease (AD). Alzheimer ’ s disease is characterized by the accumulation of extracellular amyloid beta (Aβ) and abnormally hyperphosphorylated intracellular tau filaments in neurons ...
Aberrant cholesterol metabolism has been implicated in Alzheimer's disease (AD). Recent findings have suggested an interaction of Niemann-Pick C1 (NPC1) and ATP-binding cassette transporter A1 (ABCA1 ...
In the past year, approximately 100 studies concerning the genetics of Alzheimer ' s disease were published around the world. Results suggest that the risk of Alzheimer ' s disease is modulated ...
. Alzheimer ’ s disease (AD), the most common neurodegenerative disease , is characterized by tau hyperphosphorylation, excessive amyloid beta (Aβ) accumulation, the formation of fibrillary tangles ...
The strongest genetic risk factor for sporadic Alzheimer ’ s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene , the major apolipoprotein involved in brain ...
and pravastatin on expression of Alzheimer's disease - related genes in human astrocytes and neuronal cells. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease - related genes ...
in a variety of tissues/organs, including the brain, recent genome-wide association studies (GWAS) have identified ABCA7 gene variants as susceptibility loci for late-onset Alzheimer ’ s disease (AD). More ...
Abstract: Cholesterol metabolism has been viewed as an important step in the development of Alzheimer's disease , since it was shown that the ɛ4 allele of apolipoprotein E (APOE) gene is a genetic ...
with amyloid pathology. G C A T T A C G genes G C A T Article Association of a Total Cholesterol Polygenic Score with Cholesterol Levels and Pathological Biomarkers across the Alzheimer’s Disease Spectrum 1 , 2 ...
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