ACC.POSTER CONTRIBUTIONS 2+ A35 Myocardial Function/Heart Failure--Basic Molecular Sunday, March 30, 2008, 9:00 a.m.-12:30 p.m. McCormick Place, South Hall 9:00 a.m. 1002-1 Mesenchymal Stem Cells Enhance Proliferation, Migration and Differentiation of Cardiac Stem Cells Chiaki Nakanishi, Masakazu Yamagishi, Kenichi Yamahara, Ikuo Hagino, Hidezo Mori, Yoshiki Sawa, Toshikatsu Yagihara, Soichiro Kitamura, Noritoshi Nagaya, National cardiovascular center, Suita, Japan, Kanazawa university, Kanazawa, Japan Background: Mesenchymal stem cells (MSC) transplantation has been proved as a promising strategy to treat failing heart. The effect of MSC is supposed to mediate mainly by the supply of cell protective, angiogenic and mitogenic factors in a paracrine manner. Recent reports have suggested that multipotent cardiac stem cells (CSC) reside in adult heart. However, there is little information about the effect of MSC transplantation on endogenous CSC. In the present study, we investigated whether MSC had paracrine effects on proliferation, migration, and differentiation of CSC in vitro. Methods and Results: CSC were isolated from neonatal rat hearts using explant method. Conditioned medium obtained from adult rat bone marrow-derived MSC significantly promoted CSC proliferation compared with standard medium. MSC-derived conditioned medium inhibited CSC apoptosis induced by hypoxia and serum starvation and significantly decreased the caspase-3 activity. Chemotaxis
End of preview. The entire article is 48 pages. To view the full-text, please rent this article to continue.
/lp/elsevier/cardiac-function-and-heart-failure-PA0rwkqejv
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Cardiac Function and Heart Failure
Follow Journal of the American College of Cardiology
, Volume 51 (10)
Elsevier – Mar 11, 2008
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
