1 <h5>Introduction</h5> The process of skin wound healing is represents a dynamic and well-ordered biological process ( Santoro and Gaudino, 2005 ). This process occurs in different phases: inflammation, proliferation and maturation. It is characterized by distinct but overlapping events such as blood vessels disruption and extravasation, coagulation, infiltration of inflammatory cells, deposition of granulation tissue and collagen, epithelialization, wound area contraction and tissue remodeling ( Baie and Sheikh, 2000; Jurjus et al., 2007 ). The initially randomly distributed collagen fibers become cross-linked and aggregated into fibrillar bundles, which gradually provide the healing tissue with increasing stiffness and tensile strength ( Bailey et al., 1975 ).</P>Nifedipine (NF) is a dihydropyridine calcium channel blocker, which blocks the trans-membrane influx of calcium ions into muscle cells causing dilatation of blood vessels and decreased total peripheral resistance leading to decreased systemic blood pressure. Interestingly, systemic use and topical application of NF has been reported in few publications to promote wound healing. In a previous study it was demonstrated that NF enhanced skin wound healing as evidenced by increase in tensile strength of 10 days-old granulation tissue in incision wounds ( Bhaskar et al., 2005 ). Likewise, the oral administration of NF
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Biopolymeric nifedipine powder for acceleration of wound healing
Samy, Wael; Elgindy, Nazik; El-Gowelli, Hanan M.
Follow International Journal of Pharmaceutics
, Volume 422 (1)
Elsevier – Jan 17, 2012
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