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-interacting protein (CHIP) was found to be the target gene for miR-21- mediated activation of hypoxia -inducible factor 1α (HIF-1α) in UCBMSCs. In summary, our study demonstrated that over- expressing miR-21 ...
it was demonstrated that an adenoviral vector carrying a reporter transgene efficiently expresses its gene product after intramyocardial injection [44], this approach to gene delivery was explored as an approach ...
over HIF-1α in the regulation of differentiation and function of BMSCs. Figure 7. Open in new tabDownload slide Hypoxia -inducible factor α (HIF-α) contribution to bone marrow stromal cell (BMSC)- mediated ...
and incorporated into adenoviral vectors were generated by Zhang et al. [27]. The mouse PKGI, shRNA expression vector for PKG, was constructed using the pSilencer adeno1.0-CMV system from Ambion ( Adenoviral shRNA ...
it the ability to increase bone mass.[48] Supplementation by exogenous PEDF has been shown to inhibit Sost expression and thus provides insight into how PEDF regulates mineralisation.[47] PEDF also has a direct ...
to hypoxia contributes to islet loss after transplantation, there is lacking clarity about the regulating mechanisms in an islet graft. Islets represent approximately 1% of the pancreatic tissue but receive ...
, and that further increasing the VEGF164 concentration has little additional effect on T-cell- mediated colitis. Figure 6 View largeDownload slide Adenoviral overexpression of VEGF164 results in maximal development ...
by regulating the expression or level of cytokines and growth factors is a daunting challenge because of the temporal nature of mediator response and the interactions among literally scores of peptide mediators ...
. For example, overexpression of COX-2 has been linked to increased VEGF expression in colon cancer cells [45]. Up- regulation of VEGF by cobalt chloride-stimulated hypoxia was mediated by induction of COX-2 ...
at 4°C. Immunodetection was performed using the Elite Vector Stain ABC System ( Vector Laboratories, Burlingame, CA, http://www.vectorlabs.com). The expression levels of PTEN and nuclear GLI1 were ...
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