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Availability and antiperoxidative effects of β-carotene from Dunaliella bardawil in alcohol-drinking rats

Availability and antiperoxidative effects of β-carotene from Dunaliella bardawil in alcohol-drinking rats The present study demonstrated the high bioavailability and antiperoxidative capacity of the natural β-carotene isomer mixture of Dunaliella bardawil compared with synthetic β-carotene under alcohol-induced oxidative stress. Weanling rats were adapted to ethanol by increasing ethanol levels in their drinking water to 30% at 5% intervals per week; other rats received water with no added ethanol. One water-drinking group and one alcohol-drinking group with no dietary carotene were used as controls. Two water-drinking groups were supplemented with 1 g/kg diet β-carotene either from Dunaliella or a synthetic source, and due to reduced food intake, two ethanol-fed groups received 2 g β-carotene per kilogram of diet from each source. Following 3 months of ethanol consumption, both carotene sources were found to prevent ethanol-induced lipid peroxidation as expressed by the hepatic conjugated oxidized dienes level. However, in the algal-fed rats, hepatic carotene and vitamin A levels were higher. In addition to a lower performance of the group fed ethanol and synthetic β-carotene, there were three deaths in this group. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Nutritional Biochemistry Elsevier
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