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Journals Biochemical and Biophysical Research... Volume 319 Issue 1

Several putative polyadenylation sequences and an adenylate plus timidylate rich element (ARE) are present at the 3 ′ end of the rat advanced glycation end products receptor (RAGE) gene. Two transcripts are generated by the use of alternative polyadenylation sequences, one containing the ARE sequence in its 3 ′ -untranslated region (3 ′ -UTR). Transfections of CHO-k1 or NRK cells with constructs expressing the 3 ′ -UTRs of the transcripts fused to a green fluorescence protein mRNA show that the ARE sequence has a negative effect on protein expression correlating with a decrease in the amount of mRNA, as shown in CHO-k1 transfected cells. When transfected cells were incubated in the presence of Actinomycin D the amount of fluorescence decreased in cells transfected with the ARE sequence, indicating that this sequence induces lower mRNA stability. Thus, alternative polyadenylation signals and an ARE sequence provide a novel mechanism for the regulation of the rat RAGE gene expression.

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AU-rich elements in the mRNA 3 ′ -untranslated region of the rat receptor for advanced glycation end products and their relevance to mRNA stability

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  • Publisher Elsevier
  • Copyright Copyright © 2004 Elsevier Inc.
  • ISSN 0006-291X
  • D.O.I. 10.1016/j.bbrc.2004.04.178
  • Publisher site Get PDF  

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