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that they mimicked the sialic acid found in the cell surface and reduced the neurotoxic effect of β- amyloid in plaque. They concluded that such agents might be useful for preventing the toxic effects of β- amyloid ...
for cationic dendrimers.[35] The Aβ peptides were also reported to have high affinity for sialic acid residues.[37] The toxicity of Aβ in human neuroblastoma cells was shown to be reduced by sialic acid –PAMAM ...
Abstract Neuroinflammation is a key contributor to the pathology of Alzheimer’s disease (AD). CD33 (Siglec-3) is a transmembrane sialic acid -binding receptor on the surface of microglial cells. CD33 ...
). In this regard, IBs represent a paradigmatic example of non- toxic amyloids , associated with a diversity of functions and whose prevalence in living beings seems to be more spread than previously expected (Badtke ...
analogs Ganglioside is a sialic acid that contains glycosphingolipids and is found on cellular surface glycans of neuronal cells. They perform a crucial role in the development, defense, and restoration ...
. the injectisome, type 4 pili, curli chaperone-usher pili or conjugative pili. This review also details the gene regulatory network of these numerous SCFs at the various stages as it occurs from pre-transcriptional ...
population disrooting the actively proliferating tumor bulk. Since all-trans retinoic acid (ATRA) is known as a modulator of differentiation and proliferation, we sought to elucidate whether ATRA induces ...
progression are questions relating to mechanisms of plaque regression and stabilization induced following marked LDL-cholesterol (LDL-C) reduction by lipid-lowering agents.15–19 Finally, the potential ...
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