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Journals Infection, Genetics and Evolution Volume 11 Issue 7

Highlights ► Production of tumor necrosis factor (TNF)-α and interferon (IFN)-γ may be influenced by gene polymorphisms of TNFA and PD1 . ► This study determined the associations of serum TNF-α and IFN-γ levels with TNFA and PD1 polymorphisms in chronic HBV patients and healthy controls. ► Patients with PD1 −606 AA genotype had lower TNF-α and IFN-γ levels. HBV patients with PD1 + 8669 GG genotype altered TNF-α to higher levels. ► HBV patients with PD1 −606/+8669 haplotype A/A or haplotype G/A tended to have significantly lower or higher TNF-α and IFN-γ levels, respectively. ► PD1 polymorphisms may influence PD-1 function and thus influence T-cell activation and function, leading to altered cytokines secretion.

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Altered TNF-α and IFN-γ levels associated with PD1 but not TNFA polymorphisms in patients with chronic HBV infection

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  • Publisher Elsevier
  • Copyright Copyright © 2011 Elsevier B.V.
  • ISSN 1567-1348
  • D.O.I. 10.1016/j.meegid.2011.06.004
  • Publisher site Get PDF  

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