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syndrome (IBS). Activation of central and peripheral corticotropin ‐ releasing factor (CRF) receptors is key to stress‐induced changes in gastrointestinal (GI) function. Methods This study utilised ...
The corticotropin - releasing factor (CRF) signaling systems encompass CRF and the structurally related peptide urocortin (Ucn) 1, 2, and 3 along with 2 G-protein coupled receptors , CRF1 and CRF2. CRF ...
in the pathophysiology. Corticotropin - releasing factor (CRF) is a main mediator of stress responses and mediates these gastrointestinal functional changes. CRF in brain and periphery acts through two subtype receptors ...
The characterization of corticotropin releasing factor (CRF) and, more recently, the discovery of additional CRF‐related ligands, urocortin 1, urocortin 2 and urocortin 3, the cloning of two distinct ...
criteria. Psychosocial factors are key components in the outcome of clinical manifestations of IBS symptoms. Anxiogenic and endocrine responses to stress are mediated by the corticotropin - releasing factor ...
WAS significantly increased the threshold of VMR, and this effect was no longer detected at 24 h after. Intraperitoneal injection of astressin2‐B (200 μg/kg), a corticotropin releasing factor (CRF) receptor type 2 ...
Abstract The potential relationship between stress and irritable bowel syndrome (IBS) symptomatology suggests a possible role for stress‐mediating hormones, such as corticotropin ‐ releasing factor ...
The corticotropin - releasing factor (CRF) system has been strongly associated with gastrointestinal pathophysiology, including colorectal cancer (CRC). We previously showed that altered expression ...
of Peripheral Corticotropin - Releasing Factor Receptor Type 1 and Type 2 Signaling to Induce Colonic Contractions and Visceral Hyperalgesia in Rats Tsukasa Nozu, Kaoru Takakusaki, and Toshikatsu Okumura ...
Abstract Corticotropin releasing factor (CRF) is an important mediator in the stress response. Previous studies in rodent models demonstrated that stress‐induced colonic hypersensitivity ...
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