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Journals Journal of Surgical Research Volume 100 Issue 2

5 Groups BF (n 8) BF celecoxib (n H/F (n 22) H/F celecoxib (n *P Mortality (%) 0 11.0 22.7 40.9†NEC (%) 0 25.0 35.3 84.6* Mean NEC grade NA 0.5 0.10 1.0 0.25 1.75 0.36 0.08 by 9) 22) 0.02 vs all groups by Fisher’s Exact; †P expression appears to have a protective effect on the gut mucosa via the production of cytoprotective prostaglandins. Upregulation of mucosal COX-2 following stress, such as hypoxia and formula feeding, may be a compensatory mechanism to maintain mucosal ASSOCIATION FOR ACADEMIC SURGERY—ABSTRACTS integrity and gut barrier function. Dysregulation and/or dysfunction of COX-2 in the neonatal intestine may contribute to the pathogenesis of NEC. 6. Neutral Endopeptidase Is a Determinant of Severity in a Model of Pancreatitis-Associated Lung Injury. A. M. Lightner, M.D., T. H. Jordan, B.S., C. M. Jaffray, M.D., E. F. Grady, Ph.D., and K. S. Kirkwood, M.D. University of California at San Francisco, San Francisco, California. Intraperitoneal pancreatic elastase induces lung injury similar to pancreatitis-associated lung injury by an unknown mechanism that may involve neurogenic inflammation. Neutral endopeptidase (NEP) is a cell-surface metalloprotease that preferentially degrades the proinflammatory neuropeptide substance P. Inhibition of NEP has been shown

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Abstracts Presented for the Thirty-Fifth Annual Meeting of the Association for Academic Surgery

Journal of Surgical Research , Volume 100 (2)
Elsevier – Oct 1, 2001

More Info
  • Publisher Elsevier
  • Copyright Copyright © 2001 Elsevier Ltd
  • ISSN 0022-4804
  • D.O.I. 10.1006/jsre.2001.6265
  • Publisher site Get PDF  

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