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structural relationships between the of a strong resemblance between the 270-317) consisting of two three aminoacyl transfer-RNA ( tRNA) structures of the catalytic domains standed J3-sheets which form a J3 ...
can act as co- repressors or inducers in these engineered switches by regulating TALE protein dimerization. This approach is distinct from two elegant prior in vitro studies that did not explore gene ...
that either stiffen the looped DNA leading to derepression (Figure 1C), or that introduce a kink within the loop, facilitating repression (Figure 1D). Lac repressor and TALE derivatives (Figure 1E ...
transcription factors can act as either 8. Cifuentes-Rojas, C. et al. Mol. Cell 55, 171–185 2. Di Croce, L. & Helin, K. Nat. Struct. Mol. Biol. 20, (2014). gene activators or repressors in a condition- 1147–1155 ...
repressors through their interactions with transcriptional corepressors, Atrophin family proteins, and histone-tail/chromatin-modifying factors such as lysine-specific histone demethylase 1 and histone ...
activator-like effector scaffold. In contrast to the existing Tail to Tail (TtT) and head to Head (HtH) nuclease architectures based on the symmetrical association of two TALE DNA binding domains fused ...
/ncomms1962 Received 4 Apr 2012 | Accepted 19 Jun 2012 | Published 24 Jul 2012 Comprehensive interrogation of natural TALE DnA-binding modules and transcriptional repressor domains 1,2,3 4 1,2 1,2 1,2 Le Cong ...
-binding domain of TALEs can be reprogrammed to target nearly any DNA sequence. Here, we designed and optimized a two -component AND-gate system for synthetic circuits in plants based on TALEs . In this system ...
in activating the endogenous loci and in the application of reprogramming somatic cells to iPS cells. Nevertheless, repression by CRISPR/dCas9 is comparable to or even better than TALE repressors . We demonstrated ...
as we might conduct experiments, we are naturally predisposed to making observations and drawing conclusions most closely related to our own areas of expertise. These two tales of HUB1 remind us always ...
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