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12. Wohlin P , Zeisig M, Gustafsson JA, Möller L. 32 - P -HPLC analysis of DNA adducts formed in vitro and in vivo by 2 -amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2 -amino-3,4,8-trimethyl-3H ...
of ABZ with HOCl provides an easy, convenient method for preparing dGp-ABZ. hypochlorous acid, aromatic amines, DNA adducts , N -acetylbenzidine, benzidine. The neutrophile/monocyte- derived oxidant ...
, tamoxifen- derived DNA adducts were detected in liver DNA by 32P- postlabelling with TLC (Figure 1). At the lower dose (4.5 mg/kg), the mean adduct level was 3.2 adducts /108 nt, while at the 10-fold higher dose ...
to that from controls or polyp patients (* P < 0.05, analysis of variance Fischer’s PLSD). Fig. 2 Open in new tabDownload slide Mean levels of the specific DNA adducts G and L in control mucosa (C) ( n = 10 ...
mammoplasty. DNA adduct analysis in breast tissue was performed by 32P- postlabelling analysis . Spearman rank correlation coefficients (r) were calculated to examine the association of meat consumption ...
(NPL) analysis To establish the identity of adducts visualized by NPL chromatographic analysis , specific adducts were produced: N -hydroxy- 2 -aminofluorene ( N -hydroxy-AF) was reacted with DNA to produce dG ...
- postlabelling ( DNA adducts ). Thus, it is possible that the potency in terms of DNA damage for N -OH- 2 -AF is different in both assays. One possible explanation is that the N -OH- 2 -AF- derived DNA adducts are more ...
analysis of 32P- postlabeled 2 -amino-1-methyl-6-phenylimidazo[4,5-b]pyridine- DNA adducts using in-line precolumn purification. J. Chromatogr. B. , 679, 91–101. Google Scholar 21 Frandsen,H., Grivas,S ...
). Fig. 3. Open in new tabDownload slide Structures of DNA adducts derived from N -acetoxy-3-aminobenzanthrone ( N -Aco-ABA) or N -acetoxy- N - acetyl -3-aminobenzanthrone ( N -Aco- N -Ac-ABA). Ac = −C(O)CH3; dR = 2 ...
in new tabDownload slide HPLC analysis of TAM– DNA adducts in endometrial tissues. A standard of the trans (fr-1 and fr- 2 ) or cis forms (a mixture of fr-3 and fr-4) of 32 P -labeled dG 3′ P - N 2 -TAM ...
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