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Journals Molecular Immunology Volume 42 Issue 4

2B4 (CD244) is expressed by memory-phenotype CD8 + T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes. We have employed 2B4-deficient mice and antibody blocking to analyze 2B4 function both in vitro and in vivo and found that 2B4 is a receptor with multiple functions. 2B4 is required for optimal activation of CD8 + T cells and NK cells – in this context 2B4 requires interaction with CD48 on neighboring lymphocytes, demonstrating that homotypic interaction within NK cell or T cell populations augments immunity. When 2B4 is engaged by CD48 on a target cell, 2B4 conversely inhibits NK effector function. As an inhibitory receptor, 2B4 is unconventional as it is not regulated by MHC class I molecules. In this review we will discuss the significance of these multiple functions and the events that may regulate differential 2B4 signaling outcome.

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2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8 + T cells

McNerney, Megan E.; Lee, Kyung-Mi; Kumar, Vinay
Molecular Immunology , Volume 42 (4)
Elsevier – Feb 1, 2005

More Info
  • Publisher Pergamon
  • Copyright Copyright © 2004 Elsevier Ltd
  • ISSN 0161-5890
  • D.O.I. 10.1016/j.molimm.2004.07.032
  • Publisher site Get PDF  

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