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Abstract: Ginsenoside 20 ( S )‐protopanaxadiol, one of metabolites of ginseng saponins, has been well characterized to possess the pleiotropic anticancer capabilities in several cancer cell lines ...
in human liver microsomes with an IC50 value of more than 100μM. Ppt, the intestinal metabolite of 20 ( S )- protopanaxatriol derivatives, exhibited stronger inhibition against CYP3A4 activity in human liver ...
., Shin , M. K., Kim , J. D., Kim , J. B., Chung , H. T. ( 2004 ) 20 ( S )- Protopanaxatriol , one of ginsenoside metabolites , inhibits inducible nitric oxide synthase and cylcooxygenase-2 expressions through ...
, Wang Z. Ginsenoside 20 ( S )-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells, Basic Clin. Pharm. Toxicol. , 2006, vol. 98 (pg. 588- 592) Google Scholar ...
change the biotransformation pathway of ginsenoside Rb1 by inhibiting the formation of the intermediate metabolite gypenoside-XVII. GH21 was identified as a Cladosporium cladosporioides species based ...
microflora to their active forms before they are absorbed into the blood and exert their pharmacological activities.[7] Among the metabolites of ginsenosides , 20 ( S )-protopanaxadiol 20 -O-β-d-glucopyranoside ...
tabDownload slide HPLC analysis of the time course of the transformation of ginsenoside Rb2 by Bgp3. S ginsenoside standards, 1 metabolite 1, 2 metabolite 2 Metabolites 1 and 2 from the transformation were ...
, including ginsenosides Ra (1,2,3), Rb (1,2,3), Rc, Rd, Rg3, Rh2, F2, compound K and glycosyl PD. Ginseng triol type-B type is originally 20 ( S )- protopanaxatriol , which contains ginsenoside Re, Rg1, Rg2, Rh1 ...
of two glucose units at the C-3 position. Furthermore, ginsenoside Rb1 can be transformed into CK, by the removal of two glucose units at the C-3 position and one glucose unit at the C- 20 position, while ...
KS et al. Preventive effect of 20 ( S )- ginsenoside Rg3 against lipopolysaccharide-induced hepatic and renal injury in rats . Free Radic Res 2007 ; 41 : 1181 – 1188 . Google Scholar Crossref Search ADS ...
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