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-canonical autophagy pathway. This β1- integrin -dependent c-Met-sustained signalling on ARE supports anchorage - independent cell survival and growth , tumorigenesis, invasion and lung colonization in vivo. RTK ...
Historically, a hallmark of tumorigenesis was the ability to grow in an anchorage - independent manner. Hence, tumors were thought to proliferate and survive independently of integrin attachment ...
factor (HGF). Here we show that RNAi-mediated silencing of CD151 expression in cancer cells impairs HGF-driven proliferation, anchorage - independent growth , protection from anoikis, and tumor progression ...
, such as migration, invasion and growth , by (i) a GJIC-dependent pathway; (ii) a mechanism requiring Cx26 transport to the cell surface; or (iii) a mechanism where Cx26 expression alone was sufficient. The expression ...
characteristic of oncogenic transformation, including anchorage - independent growth , invasiveness , suppression of anoikis and tumorigenicity in nude mice. In order to determine if ILK overexpression can result ...
in the nude mouse. Among these features, anchorage - independent growth capability (in vitro) correlates well with tumour formation in the nude mouse (in vivo) ( 1 –3), and is therefore a prominent characteristic ...
with the alpha5beta1 integrin of extravillous trophoblast (EVT) cell surface to stimulate its migration in an IGF- independent manner.This migration stimulation has also been shown to require activation of extracellular ...
. Previous studies have shown that β1 integrins play a prominent role in the invasiveness and metastatic potential of MDA-MB-231 cells (29,30). β1 integrins , which are required for growth , differentiation ...
Metastasis Rev 2008 ; 27 : 715 – 735 Google Scholar Crossref Search ADS PubMed WorldCat 75 Fiucci G , Ravid D, Reich R et al. Caveolin- 1 inhibits anchorage - independent growth , anoikis and invasiveness in MCF-7 ...
sarcoma patients. Endoglin knockdown in tumor cells interferes with tumor cell plasticity and reduces invasiveness and anchorage - independent growth in vitro. Ewing sarcoma and melanoma cells with reduced ...
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