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Wound degradomics – current status and future perspectives

Wound degradomics – current status and future perspectives Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic activity at the wound site is a major factor in the pathology of chronic wounds. A large body of data acquired in many years of research provide a good understanding of how individual proteases may influence the repair process. The next challenge will be to integrate these findings and to elucidate the complex interactions of proteolytic enzymes, their inhibitors and substrates on a system-wide level. Here, we present novel approaches that might help to achieve this ambitious goal in cutaneous wound healing research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Chemistry de Gruyter

Wound degradomics – current status and future perspectives

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Publisher
de Gruyter
Copyright
©2011 by Walter de Gruyter Berlin Boston
Subject
HIGHLIGHT: THE WINTER SCHOOL ON PROTEINASES AND THEIR INHIBITORS
ISSN
1431-6730
eISSN
1437-4315
DOI
10.1515/BC.2011.092
pmid
21819269
Publisher site
See Article on Publisher Site

Abstract

Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic activity at the wound site is a major factor in the pathology of chronic wounds. A large body of data acquired in many years of research provide a good understanding of how individual proteases may influence the repair process. The next challenge will be to integrate these findings and to elucidate the complex interactions of proteolytic enzymes, their inhibitors and substrates on a system-wide level. Here, we present novel approaches that might help to achieve this ambitious goal in cutaneous wound healing research.

Journal

Biological Chemistryde Gruyter

Published: Nov 1, 2011

Keywords: protease web; proteolysis; proteomics; skin; wound healing

There are no references for this article.