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Günther, Schmaibeck, Dorn u. Merker: Struktur und Funktion des braunen Fettgewebes im Mg-Mangel Z. Klin. Chem. Klin. Biochem. 10. Jg. 1972, S. 425--429 Von TH. GÜNTHER, J. SCHMALBECK, F. DORN und H. J. MERKER1) Zentralinstitut für Biochemie und Biophysik^ Physiologisch-Chemisches Institut und II. Anatomisches Instittit der Freien Universität Berlin (Eingegangen am 29. Februar/15. Juli 1972) Nach einer Abnahme der Serum Mg-Konzentration infolge Mg-armer Ernährung sind in den braunen Fettzellen der Ratte die Zahl und Größe der Fetteinschlüsse stark reduziert sowie die Mitochondrien stark geschwollen. Diese Veränderungen lassen sich mit einer erhöhten Lipolyse, die auch durch die Lipidanalyse bestätigt wurde, und einer Entkopplung der oxidativen Phosphorylierung in vivo erklären. Als Ursache wird eine vermehrte Bildung von 3', 5'-AMP im Mg-Mangel diskutiert. The structure and function of the brown fat tissue of the rat in Mg-deficiency When the serum concentration of magnesium decreases as a result of an Mg-deficient diet, the size and number of the fat inclusions is markedly decreased in the brown fat cells and the mitochondria are markedly swollen. These changes can be explained on the basis of increased lipolysis, which was confirmed by lipid analysis, and an uncoupling of oxidative phosphorylation in vivo. This is thought
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1972
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