Reference Materials — A Main Element in a Coherent Reference Measurement System

R. Dybkaer

doi:10.1515/cclm.1991.29.4.241

$Introduction An important goal of the clinical laboratory sciences is to produce results of measurement that afe clinically relevant, cost-effective and reliable. The required reliability of a given type of quantity should be based pn stated clinical needs coupled with a knowledge of biological conditions and analytical possibilities. Analytical reliability is measured by 'performance characteristics such äs analytical calibration function, analytical sensitivity, analytical specificity, recovery, repeatability Standard deviation, reprodücibility Standard deviation, bias, limit of detection, and limits of determination. They determine the uncertainty of measurement, comprising random and systematic components, determining the interval where the true value of a quantity is likely to lie. The analytical reliability, together with biological, pathological, and therapeutic factors, determine the clinical reliability of a given type of quantity äs expressed by the number fraction of correct classifications of the clinical Status of persons, based on the results of measurement. The establishment and maintenance of the stipulated analytical reliability of a measurement procedure requiire a coherent reference measurement System comprising recognized organizations, institutions, laboratories, and industries; scientifically based sets of quantities, units, and reference data; hierarchies of interrelated measurement procedures and measurement Standards. All these elements contribute to a quality assurance scheme giving$

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Reference Materials — A Main Element in a Coherent Reference Measurement System

Dybkaer, R.

Follow Clinical Chemistry and Laboratory Medicine , Volume 29 (4) de Gruyter – Jan 1, 1991

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Reference Materials — A Main Element in a Coherent Reference Measurement System

Dybkaer, R.

Follow Clinical Chemistry and Laboratory Medicine , Volume 29 (4) de Gruyter – Jan 1, 1991

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