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Protein aggregation in crowded environments

Protein aggregation in crowded environments Abstract The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Chemistry de Gruyter

Protein aggregation in crowded environments

Ellis, R. John; Minton, Allen P.
Biological Chemistry , Volume 387 (5) – May 1, 2006
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Publisher
de Gruyter
Copyright
Copyright © 2006 by the
ISSN
1431-6730
eISSN
1437-4315
DOI
10.1515/BC.2006.064
pmid
16740119
Publisher site
See Article on Publisher Site

Abstract

Abstract The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.

Journal

Biological Chemistry – de Gruyter

Published: May 1, 2006

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