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Introduction , , ^ It is generally agreed that the concentration of free thyroxine io serum is the most useful clinical test in assessing thyroid function, since the free hormone available to the peripheral tissues is responsible for the hormonal action (1). The quantity of thyroxine binding globulin to which thyroxine is almost entirely bound, is altered in many clinical states. An increase is related to excess estrogens in pregnancy or in women receiving oral contraceptives and a decrease may arise from andre* genie anabolic steroids (2). Due to alterations in thyroxine binding blobulin concentration, total thyroxine estimation (T4D) and radioactive J. Oin. Chem, Clin. Biochem. / Vol. 16,1978 / No. 4 T3 uptake (RT^U) may lead to an incorrect diagnosis of hyper- or hypothyroidism. However, determination of ^ ftee th oxine fraction (Le. the prOpOrtiOn of total thyroxine present in the free form) is tedious and too complex for routine clinical use. An indirect measurement of ffee thyroxine in the serum is given by the product of thyroxine concentration and T3 uptake, the T4-RT3U iRd?x whjch tenda to refject the thyroid status unaltered by ch Another ^ Q{ thyroxine binding globu]in concentration, using ? normaiised approach is
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1978
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