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National screening program vs. standardized neurodevelopmental follow-up

National screening program vs. standardized neurodevelopmental follow-up Background: Long-term follow-up is urgently needed to decide on the consequences of new therapies. Objective: This study assesses the use of a national child development screening program for a follow-up examination of a defined patient group. Patients and methods: Neurodevelopmental outcome of 139 survivors after intrauterine laser coagulation for severe twin-twin transfusion syndrome was investigated both according to a standardized neurodevelopmental follow-up and according to the pediatricians' screening examinations. Results: Screening and standardized tests revealed identical results in 90.6% of the cases. Using the national screening program only four out of 139 children (2.9%) with minor neurological disabilities would have been missed. For identifying mild or severe neurodevelopmental abnormalities the screening has a sensivity of 78% and a specifity of 93%. The positive predictive value is 61% and the negative predictive value 97%. Conclusions: The use of already available and established follow-up programs for extended follow-up studies would considerably reduce costs, time and manpower. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Perinatal Medicine de Gruyter

National screening program vs. standardized neurodevelopmental follow-up

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References (6)

Publisher
de Gruyter
Copyright
©2009 by Walter de Gruyter Berlin New York
Subject
Short communication
ISSN
0300-5577
eISSN
1619-3997
DOI
10.1515/JPM.2009.008
pmid
18759686
Publisher site
See Article on Publisher Site

Abstract

Background: Long-term follow-up is urgently needed to decide on the consequences of new therapies. Objective: This study assesses the use of a national child development screening program for a follow-up examination of a defined patient group. Patients and methods: Neurodevelopmental outcome of 139 survivors after intrauterine laser coagulation for severe twin-twin transfusion syndrome was investigated both according to a standardized neurodevelopmental follow-up and according to the pediatricians' screening examinations. Results: Screening and standardized tests revealed identical results in 90.6% of the cases. Using the national screening program only four out of 139 children (2.9%) with minor neurological disabilities would have been missed. For identifying mild or severe neurodevelopmental abnormalities the screening has a sensivity of 78% and a specifity of 93%. The positive predictive value is 61% and the negative predictive value 97%. Conclusions: The use of already available and established follow-up programs for extended follow-up studies would considerably reduce costs, time and manpower.

Journal

Journal of Perinatal Medicinede Gruyter

Published: Jan 1, 2009

Keywords: Laser coagulation; neurodevelopmental follow-up; preterm infant; screening examinations; twin-twin transfusion syndrome

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