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Letter to the Editor

Letter to the Editor Letter Eur. J. Clin. Chem. Clin. Biochem. Vol. 31, 1993, p. 541 © 1993 Walter de Gruyter & Co. Berlin · New York «litre» is Not an Internationally Recognized Quantity Sir, The use of the concept "titre" as a kind of quantity in immunological measurements is very widespread in clinical laboratory sciences. This concept is, however, not recognized by the international scientific organizations dealing with metrology (1). Therefore, in this letter we propose abandoning the use of the concept (and the term) "titre" and replacing it by another concept more consistent with metrology. The concept "titre" (in USA spelled "titer") is defined by the National Committee for Clinical Laboratory Standards (2) as the reciprocal of the dilution factor required to produce a defined outcome in a defined system. This concept is mainly applied to the analytical procedures based on the macroscopic or microscopic visualization ("positive" result) of an antibody-antigen reaction, in which the reagents used contain particles of charcoal, latex or erythrocytes, covered by an antigen or an antibody. When a "positive" result is obtained a series of dilutions (!/2, l/4, l/e, etc.) of the specimen is performed and analyzed, and the final result is reported as a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Letter to the Editor

Clinical Chemistry and Laboratory Medicine , Volume 31 (8) – Jan 1, 1993
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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.8.541
Publisher site
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Abstract

Letter Eur. J. Clin. Chem. Clin. Biochem. Vol. 31, 1993, p. 541 © 1993 Walter de Gruyter & Co. Berlin · New York «litre» is Not an Internationally Recognized Quantity Sir, The use of the concept "titre" as a kind of quantity in immunological measurements is very widespread in clinical laboratory sciences. This concept is, however, not recognized by the international scientific organizations dealing with metrology (1). Therefore, in this letter we propose abandoning the use of the concept (and the term) "titre" and replacing it by another concept more consistent with metrology. The concept "titre" (in USA spelled "titer") is defined by the National Committee for Clinical Laboratory Standards (2) as the reciprocal of the dilution factor required to produce a defined outcome in a defined system. This concept is mainly applied to the analytical procedures based on the macroscopic or microscopic visualization ("positive" result) of an antibody-antigen reaction, in which the reagents used contain particles of charcoal, latex or erythrocytes, covered by an antigen or an antibody. When a "positive" result is obtained a series of dilutions (!/2, l/4, l/e, etc.) of the specimen is performed and analyzed, and the final result is reported as a

Journal

Clinical Chemistry and Laboratory Medicine – de Gruyter

Published: Jan 1, 1993

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