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© 2001 Blackwell Wissenschafls-Verlag, Berlin Schlüsselwörter: ELISA; IFT; PCR; Antigennachweis; PCR. is caused mainly herpes simplex H erpes genitalisfrequency, and to abylesser extentvirus virus type 2 (HSV-2), but with increasing by herpes simplex type 1 (HSV-1) [1-3]. Coinfection with both types has been described [4]. Occasionally, local reactivation of varicella zoster virus in genital dermatomes is observed. Primary genital HSV infection is followed by latent infection in the sacral ganglia where recurrent reactivation takes place. Today, the diagnosis o£ genital herpes is based on laboratory methods. Due to the overlap of clinical presentation of veneral diseases, clinical diagnosis of genital herpes can be made with reasonable certainty only in a minority of patients. A sensitivity of 35 % but a 94 % specificity of diagnosis of genital herpes in men on clinical grounds was reported [5]. Since most patients are unaware that they have genital herpes and since virtually all persons who are HSV-2 positive shed virus intermittently, identification of subclinical infections is important [2, 6]. Pregnant women close to term are of particular concern in order to prevent perinatal transmission [7]. It is impossible clinically to distinguish between primary and recurrent infection, which has lower rate of
Laboratoriums Medizin / Journal of Laboratory Medicine – de Gruyter
Published: Jan 1, 2001
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