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INSTAND-Mitteilung

INSTAND-Mitteilung INSTAND-Mitteilung Problems with the Measurement of Human Choriongonadofropin (hCG) in External Quality Assessment Surveys Probleme bei der Messung von humanem Choriongonadotropin (hCG) in Ringversuchen W. G. Wood1·2, R. Hanke3, H. Reinauer4 Summary: The Institute for Standardisation and Documentntion in Medical Laboratories (INSTAND) carries out regulär extcrnal quality assessment surveys in nccordance with the Calibration Act of the Federal Republic of Germany. In this brief report, the state of l he art of assays for human chorion gonadotropin (hCG) is discussed, taking results from surveys between October 1993 and January 1996 into account. Four serum samples were distributed several times over the observation period and a fifth serum, a recalcified plasma (blood group 0, Rh positive) was sent äs a control for the reference ränge for men and nonpregnant women.The results showed a worsening of the comparison between methods, especially for assays measuring intact hCG. Whereas all methods could be compared in one group at the beginning of the observation period, with inter-laboratory coefficients of Variation under 20%, this was no longer possible after October 1994, where differences between measured concentrations were almost a factor of two in the most extreme cases. The aim of this publication was to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Laboratoriums Medizin / Journal of Laboratory Medicine de Gruyter

INSTAND-Mitteilung

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
0342-3026
eISSN
1439-0477
DOI
10.1515/labm.1996.20.10.568
Publisher site
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Abstract

INSTAND-Mitteilung Problems with the Measurement of Human Choriongonadofropin (hCG) in External Quality Assessment Surveys Probleme bei der Messung von humanem Choriongonadotropin (hCG) in Ringversuchen W. G. Wood1·2, R. Hanke3, H. Reinauer4 Summary: The Institute for Standardisation and Documentntion in Medical Laboratories (INSTAND) carries out regulär extcrnal quality assessment surveys in nccordance with the Calibration Act of the Federal Republic of Germany. In this brief report, the state of l he art of assays for human chorion gonadotropin (hCG) is discussed, taking results from surveys between October 1993 and January 1996 into account. Four serum samples were distributed several times over the observation period and a fifth serum, a recalcified plasma (blood group 0, Rh positive) was sent äs a control for the reference ränge for men and nonpregnant women.The results showed a worsening of the comparison between methods, especially for assays measuring intact hCG. Whereas all methods could be compared in one group at the beginning of the observation period, with inter-laboratory coefficients of Variation under 20%, this was no longer possible after October 1994, where differences between measured concentrations were almost a factor of two in the most extreme cases. The aim of this publication was to

Journal

Laboratoriums Medizin / Journal of Laboratory Medicine – de Gruyter

Published: Jan 1, 1996

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