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Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review

Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review The current worldwide prevalence of type 2 diabetes (T2D) was estimated to be 2.8% in 2000, but it is predicted to increase to epidemic proportions in the coming decades, primarily due to lifestyle changes, particularly obesity. In the United Kingdom there are over 1.4 million men and women with T2D. In addition to a strong environmental element, the existence of an underlying genetic component to T2D risk is supported by twin studies, family studies and the widely different T2D prevalence across ethnic groups. Here we review data showing that several common genetic risk variants for T2D have now been successfully identified, with modest, but meta-analytical robust effects on risk (in the region of 1.1–1.5-fold risk per allele). Use of these in combination may have clinical utility in identifying subjects at high risk. Whether this information will be motivating to make the type of lifestyle changes that have been shown to reduce the rate of progression from the pre-diabetes state to overt T2D is discussed. Clin Chem Lab Med 2007;45:301–8. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review

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References (70)

Publisher
de Gruyter
Copyright
©2007 by Walter de Gruyter Berlin New York
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/CCLM.2007.070
pmid
17378723
Publisher site
See Article on Publisher Site

Abstract

The current worldwide prevalence of type 2 diabetes (T2D) was estimated to be 2.8% in 2000, but it is predicted to increase to epidemic proportions in the coming decades, primarily due to lifestyle changes, particularly obesity. In the United Kingdom there are over 1.4 million men and women with T2D. In addition to a strong environmental element, the existence of an underlying genetic component to T2D risk is supported by twin studies, family studies and the widely different T2D prevalence across ethnic groups. Here we review data showing that several common genetic risk variants for T2D have now been successfully identified, with modest, but meta-analytical robust effects on risk (in the region of 1.1–1.5-fold risk per allele). Use of these in combination may have clinical utility in identifying subjects at high risk. Whether this information will be motivating to make the type of lifestyle changes that have been shown to reduce the rate of progression from the pre-diabetes state to overt T2D is discussed. Clin Chem Lab Med 2007;45:301–8.

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Mar 1, 2007

Keywords: genetic testing; motivation; obesity; type 2 diabetes

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